Possible roles of prostaglandin(PG)E1 in dog coronary circulation

Coronary circulation in the conscious dog with cardiac neural ablation.

Dynamics of atrial peptide secretion in the coronary circulation of the conscious dog.

The secretion of atrial natriuretic peptide by the heart is not simply the arterial-coronary sinus concentration difference times coronary blood flow, because only a small fraction of total coronary blood flow passes through the atria. We measured coronary sinus and arterial plasma atrial natriuretic factor (ANF) concentrations and blood flow to each part of the heart using the radioactive micr...

Effects of norepinephrine on coronary circulation and left ventricular dynamics in the conscious dog.

The effects of norepinephrine (0.1 and 1.0 Mg/kg, iv) on coronary blood flow and resistance, left ventricular pressure and diameter, dP/dt, (dP/dt)/P, and the velocity (Vlso) of myocardial fiber shortening were studied in conscious dogs. When the heart rate was held constant, norepinephrine caused an initial reduction in coronary vascular resistance which was associated with increases in mean a...

Hyperemic response of the coronary circulation to brief diastolic occlusion in the conscious dog.

This study was undertaken to determine whether coronary blood flow can be regulated in response to coronary arterial occlusions briefer than a single diastole. The possible involvement of metabolic vs. myogenic mechanisms in such regulation was investigated. Eleven conscious dogs with experimentally produced complete heart block, chronically implanted electromagnetic flow probes, and pneumatic ...

Coronary Circulation

T he effects of hypertension and hypertrophy on the coronary circulation are subjects of increasing investigative interest.1-3 Animal studies have shown that the major conduit arteries are enlarged in pressure-overloaded, hypertrophied ventricles, but this increase falls short of paralleling the extent of hypertrophy.4 This enlargement is accompanied by an increase in the extracellular componen...